Uppsala Monitoring Centre (UMC) researcher Kristina Star successfully defended her PhD thesis Safety of medication in paediatrics on 16th May 2013 at Uppsala University.
The overall aim of this thesis was to explore the nature of reported adverse drug reactions (ADRs), and the challenges of prescribing and administering medicines for paediatric patients. The enhanced understanding will be used as a basis for developing separate signal detection processes in VigiBase reports issued for children.
Suspected ADRs reported for children worldwide were reviewed quantitatively and in-depth. The thesis exemplified prescribing difficulties for general practitioners (GP) relating to dosage form and challenges in medication practices for nurses in paediatric care. The studies were based on VigiBase, the UK IMS Disease Analyzer and on interviews with nurses from two hospitals in Sweden. The thesis covered aspects of both commonly and more rarely used medicines in all paediatric age groups, from neonates to adolescents. As a continuation of the work of this thesis, UMC is currently working to define clinical focus areas in which the unique VigiBase global data is reviewed for problems when there are few reports from individual countries.
The whole thesis is available from http://uu.diva-portal.org/smash/get/diva2:613743/FULLTEXT01
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